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At first glance, scientific laboratory experiences might appear to be challenging to move to the cloud. Skeptics may point to sensory feedback limitations and inequivalence of student outcomes. Emerging data increasingly provides evidence that scientific laboratory courses are not only amenable to online learning but can deliver student outcomes at or above traditional in-person courses. In identifying a science lab format, each institution weighs factors like lab course goals, budget, program growth, access and safety differently. The following highlights a decision matrix for how one institution informed their choice for the modality of a chemistry lab course.